Treatment of brittle fingernails and onychoschizia with biotin: scanning electron microscopy
Colombo VE, Gerber F, Bronhofer M, Floersheim GL
Published in Journal of the American Academy of Dermatology
Methodology
Uncontrolled before-and-after scanning electron microscopy study of distal fingernail clippings from 32 subjects: 10 normal controls and 22 patients with brittle nails treated with oral biotin.
Key Findings
Nail thickness increased significantly by 25% in the group with matched pre/post clippings and by 7% in the second group; nail splitting was reduced and dorsal surface cell arrangement normalized.
Conclusions
Oral biotin increased nail plate thickness and reduced splitting in patients with brittle nails and onychoschizia.
Limitations
No placebo control, very small sample, historical study, non-blinded morphological assessment.
Supplements Studied
The thickness of the nails in group B increased significantly by 25%.
Outcomes Measured
The thickness of the nails in group B increased significantly by 25%.
Study Details
Access Study
Disclosures
Funding
Not reported
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