Citicoline as Adjuvant Therapy in Parkinson's Disease: A Systematic Review
Que DS, Jamora RDG
Published in Clinical Therapeutics
Methodology
Systematic review of 7 studies (2 crossover, 3 randomized controlled, 2 open prospective) on citicoline as adjunct therapy in Parkinson's disease
Key Findings
Patients taking citicoline showed improvement in rigidity, akinesia, tremor, handwriting and speech, and levodopa dose could be reduced by up to 50%.
Conclusions
Citicoline has beneficial adjuvant effects in Parkinson's disease, but heterogeneity means higher-quality studies are needed.
Limitations
Small and heterogeneous included studies, varied outcome tools, mostly older trials, no meta-analysis
Supplements Studied
Citicoline allowed effective reduction of levodopa by up to 50%.
Outcomes Measured
Citicoline increases dopamine synthesis and inhibits dopamine uptake... patients with PD who were taking citicoline had significant improvement in rigidity, akinesia, tremor, handwriting, and speech.
Study Details
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Disclosures
Funding
Not reported
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