Efficacy and safety of curcumin therapy for knee osteoarthritis: a Bayesian network meta-analysis
Zhao J, Liang G, Zhou G, Hong K, Yang W
Published in Journal of Ethnopharmacology
Methodology
Bayesian network meta-analysis of 23 randomized controlled trials of curcumin alone or combined with other drugs for knee osteoarthritis, searching PubMed, Embase and Cochrane Library to April 2023 with random-effects models
Key Findings
Curcuminoid formulations improved knee osteoarthritis pain and function relative to placebo, with combination regimens generally ranking highest and an acceptable adverse event profile.
Conclusions
Curcumin is the best-supported supplement option for symptomatic knee osteoarthritis.
Limitations
Trials mostly small and short; multiple proprietary curcumin formulations of differing bioavailability; indirect comparisons.
Supplements Studied
To evaluate the efficacy and safety of curcumin, both alone and in combination with other drugs, in KOA treatment through a Bayesian network meta-analysis (NMA).
Curcumin, a polyphenolic compound extracted from turmeric (Curcuma longa L.), is widely used in traditional Chinese medicine to treat osteoarthritis and rheumatoid arthritis.
Related Health Concerns
Study Details
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Disclosures
Funding
Not reported
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.