Iron absorption from oral iron supplements given on consecutive versus alternate days and as single morning doses versus twice-daily split dosing in iron-depleted women
Stoffel NU, Cercamondi CI, Brittenham G, Zeder C, Geurts-Moespot AJ, Swinkels DW, Moretti D, Zimmermann MB
Published in The Lancet Haematology
Methodology
Two open-label randomised crossover iron-absorption studies using stable isotopes in iron-depleted, non-anaemic women comparing dosing schedules.
Key Findings
Higher single doses raised hepcidin and reduced fractional iron absorption for up to 24 hours; alternate-day single doses produced greater total fractional absorption than daily or twice-daily dosing.
Conclusions
Alternate-day single-dose iron may maximise absorption compared with conventional daily split dosing.
Limitations
Short absorption studies with surrogate isotopic endpoints rather than clinical haemoglobin outcomes; small, all-female sample.
Supplements Studied
Alternate-day single doses produced greater total fractional iron absorption than daily or twice-daily dosing.
Outcomes Measured
Higher single doses raised hepcidin and reduced fractional iron absorption for up to 24 hours; alternate-day single doses produced greater total fractional absorption than daily or twice-daily dosing.
Related Health Concerns
Study Details
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Disclosures
Funding
Swiss Federal Institute of Technology / academic
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.