meta_analysis
    2004
    High Quality

    Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a meta-analysis

    Ziegler D, Nowak H, Kempler P, Vargha P, Low PA

    Published in Diabetic Medicine

    Key Findings

    Pooled analysis of four RCTs found intravenous alpha-lipoic acid 600 mg/day for 3 weeks significantly reduced Total Symptom Score versus placebo.

    Conclusions

    Short-term IV alpha-lipoic acid improves neuropathic symptoms in diabetic polyneuropathy.

    Limitations

    Intravenous route only; trials drawn from one manufacturer database; short duration.

    Supplements Studied

    Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a meta-analysis.

    Study Details

    Year:2004
    Sample Size:1,258
    Duration:3 weeks
    Quality Score:8/10

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