Coenzyme Q10 for heart failure
Madmani ME, Yusuf Solaiman A, Tamr Agha K, Madmani Y, Shahrour Y, Essali A
Published in Cochrane Database of Systematic Reviews
Methodology
Cochrane systematic review of randomized controlled trials comparing coenzyme Q10 with placebo or other therapy in patients with heart failure, assessing mortality, exercise capacity and quality of life
Key Findings
Included trials were small and of variable quality; evidence was insufficient to confirm or refute that coenzyme Q10 improves clinical outcomes such as exercise capacity in heart failure.
Conclusions
Available randomized evidence does not establish a clear benefit of coenzyme Q10 in heart failure.
Limitations
Small underpowered trials, heterogeneous outcome reporting, high risk of bias in several studies.
Supplements Studied
Coenzyme Q10, although not a primary recommended treatment, could be beneficial to patients with heart failure
Related Health Concerns
Study Details
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Disclosures
Funding
Cochrane Collaboration
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