systematic_review
    2019
    High Quality

    Diabetes insipidus

    Christ-Crain M, Bichet DG, Fenske WK, Goldman MB, Rittig S, Verbalis JG, Verkman AS

    Published in Nature Reviews Disease Primers

    Key Findings

    Polyuria-polydipsia syndrome is caused by central or nephrogenic diabetes insipidus or primary polydipsia; copeptin-based testing markedly improves differential diagnosis over the classic water deprivation test.

    Conclusions

    Accurate differentiation of the cause of excessive thirst and urination is essential before treatment; desmopressin is harmful in primary polydipsia.

    Limitations

    Narrative review; copeptin assays not universally available.

    Related Health Concerns

    Excessive Thirst

    Study Details

    Year:2019
    Quality Score:8/10

    Access Study

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