The hepatotoxicity of Polygonum multiflorum: the emerging role of the immune-mediated liver injury
Rao T, Liu YT, Zeng XC, Li CP, Ou-Yang DS
Published in Acta Pharmacologica Sinica
Methodology
Synthesis of epidemiological, clinical and experimental evidence on immune mechanisms of Polygonum multiflorum-induced liver injury
Key Findings
Most epidemiological and clinical evidence indicates PM-DILI is an immune-mediated idiosyncratic injury rather than simple dose-dependent toxicity.
Conclusions
Susceptible individuals can be harmed at conventional doses.
Limitations
Mechanisms incompletely elucidated; heterogeneous source studies.
Supplements Studied
However, most epidemiological and clinical evidence demonstrate that PM-DILI is immune-mediated idiosyncratic liver injury.
Related Health Concerns
Study Details
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Disclosures
Funding
Not reported
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