Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial
Didangelos T, Karlafti E, Kotzakioulafi E, Margariti E, Giannoulaki P, Batanis G, Tesfaye S, Kantartzis K
Published in Nutrients
Key Findings
Oral methylcobalamin 1 mg/day for 12 months improved neurophysiological parameters, sudomotor function, pain score and quality of life versus placebo in metformin-treated diabetic neuropathy.
Conclusions
Long-term oral B12 improves nerve function and neuropathic symptoms in patients with low B12, though not all screening measures improved.
Supplements Studied
The treatment of patients with DN with 1 mg of oral methylcobalamin for twelve months increased plasma B12 levels and improved all neurophysiological parameters, sudomotor function, pain score, and QoL, but it did not improve CARTS and MNSIE.
Related Health Concerns
Study Details
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