meta_analysis
2022
Association between MTHFR (677C>T and 1298A>C) polymorphisms and psychiatric disorder: A meta-analysis
Meng X, Zheng JL, Sun ML, Lai HY, Wang BJ, Yao J, et al.
Published in PLoS One, Vol. 17 (7), pp. e0271170
Methodology
Meta-analysis of case-control studies on MTHFR 677C>T and 1298A>C in ADHD (5 studies, 434 cases), bipolar disorder (18 studies) and schizophrenia (44 studies).
Key Findings
677C>T was associated with bipolar disorder and schizophrenia; 1298A>C was associated with ADHD and bipolar disorder.
Conclusions
MTHFR variants may contribute to the causes of several psychiatric disorders.
Limitations
The ADHD analysis rests on only five small studies; association, not cause.
Related Health Concerns
Study Details
Year:2022
Quality Score:5/10
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