Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria
Yago MR, Frymoyer AR, Smelick GS, Frymoyer A, Budha NR, Dickmann LJ
Published in Molecular Pharmaceutics, Vol. 10 (11), pp. 4032-7
Methodology
Controlled crossover study measuring gastric pH after betaine hydrochloride administration in volunteers with drug-induced hypochlorhydria.
Key Findings
Betaine hydrochloride rapidly lowered gastric pH below 3 for a median of 73 minutes, temporarily restoring an acidic digestive environment.
Conclusions
Betaine HCl can restore the gastric acidity that primes pancreatic enzyme activity.
Limitations
Small healthy-volunteer study; no clinical digestion endpoints.
Supplements Studied
Betaine hydrochloride rapidly lowered gastric pH below 3 for a median of 73 minutes
Outcomes Measured
Betaine hydrochloride rapidly lowered gastric pH below 3 for a median of 73 minutes, temporarily restoring an acidic digestive environment
Study Details
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