Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension
Lan J, Zhao Y, Dong F, Yan Z, Zheng W, Fan J, Sun G
Published in Journal of Ethnopharmacology, Vol. 161, pp. 69-81
Methodology
Meta-analysis of 27 randomised trials of berberine, the principal alkaloid in goldenseal, for glucose and lipid control
Key Findings
Berberine lowered fasting glucose, HbA1c and LDL cholesterol comparably to standard oral hypoglycaemics when combined with lifestyle change.
Conclusions
Most claimed metabolic benefits of goldenseal derive from berberine, studied almost entirely as an isolated compound rather than as goldenseal root.
Limitations
Trials mostly Chinese, small and at moderate risk of bias; berberine dose in goldenseal products is far lower.
Supplements Studied
Berberine lowered fasting blood glucose, HbA1c and LDL cholesterol comparably with standard oral hypoglycaemic agents.
Berberine lowered fasting glucose, HbA1c and LDL cholesterol comparably to standard oral hypoglycaemics when combined with lifestyle change.
Berberine, the main alkaloid in Oregon grape, lowered fasting glucose and HbA1c in pooled trials.
Related Health Concerns
Study Details
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