Berberine activates thermogenesis in white and brown adipose tissue
Zhang Z, Zhang H, Li B, Meng X, Wang J, Zhang Y, Yao S, Ma Q, Jin L, Yang J, Wang W, Ning G
Published in Nature Communications
Abstract
Study demonstrating berberine stimulates thermogenesis and browning of white adipose tissue through AMPK activation, offering a mechanism for weight management and metabolic benefits beyond glucose control.
Methodology
Preclinical rodent and cell studies of berberine effects on brown and white adipose thermogenic gene expression
Key Findings
Berberine increased energy expenditure, raised brown adipose activity and induced browning of white adipose tissue via AMPK-PGC1alpha signalling.
Conclusions
Berberine promotes adipose browning in animal models; human confirmation is lacking.
Limitations
Animal and cell data only; no human browning trial exists.
Supplements Studied
Berberine induced browning of white adipose tissue in animal models.
Outcomes Measured
Berberine induced browning of white adipose tissue via AMPK-PGC1alpha signalling.
Berberine increased energy expenditure, raised body temperature and improved cold tolerance in obese mice. It activated brown adipose tissue and induced browning of white adipose tissue, with increased UCP1 expression, via an AMPK-PGC-1alpha dependent mechanism. Fat mass and insulin resistance improved.
Berberine activates brown adipose tissue and induces browning of white adipose tissue, increasing energy expenditure in preclinical models.
Related Health Concerns
Study Details
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Disclosures
Funding
Chinese national research grants
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