rct
    2008
    High Quality

    N-acetyl cysteine for depressive symptoms in bipolar disorder: a double-blind randomized placebo-controlled trial

    Berk M, Copolov DL, Dean O

    Published in Biological Psychiatry

    Methodology

    24-week double-blind placebo-controlled trial of adjunctive N-acetylcysteine 2 g/day in bipolar disorder.

    Key Findings

    NAC improved MADRS depression scores and functioning versus placebo, with benefit lost after washout.

    Conclusions

    Adjunctive NAC showed benefit for bipolar depressive symptoms in a maintenance setting.

    Limitations

    Single trial, modest sample, high attrition.

    Supplements Studied

    NAC improved MADRS depression scores and functioning versus placebo in bipolar disorder.

    Outcomes Measured

    Depression Symptom Reduction

    NAC improved MADRS depression scores versus placebo.

    Related Health Concerns

    Bipolar Disorder
    Depression

    Study Details

    Year:2008
    Sample Size:75
    Quality Score:7/10

    Access Study

    View on DOIView on PubMedOriginal Source

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