Emodin for pulmonary fibrosis: a systematic review and meta-analysis of efficacy and molecular mechanisms
Zhou X, Sima M, Fang Z, Cui Y, Han M
Published in Frontiers in Medicine
Methodology
Systematic review and meta-analysis of emodin in animal models of pulmonary fibrosis across four international and four Chinese databases through July 2025, using SYRCLE risk-of-bias assessment
Key Findings
Emodin attenuated pulmonary fibrosis severity, inflammation and oxidative stress in animal models.
Conclusions
Provides a theoretical rather than clinical basis for use; human trials are absent.
Limitations
Animal models only; unclear translation to humans.
Supplements Studied
This systematic review and meta-analysis aimed to evaluate emodin's therapeutic efficacy in animal models of pulmonary fibrosis (PF) and summarize its anti-fibrotic mechanisms.
Study Details
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Disclosures
Funding
Not reported
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