systematic_review
    2015

    Pharmacological effects and pharmacokinetic properties of icariin, the major bioactive component in Herba Epimedii

    Wang S, Ma J, Zeng Y, Zhou G, Wang Y, Zhou W, Sun X, Wu M

    Published in Life Sciences

    Methodology

    Review of icariin pharmacology, bioavailability and toxicology across preclinical studies

    Key Findings

    Icariin has poor oral bioavailability and extensive first-pass metabolism, which limits the translation of in vitro potency to clinical effect.

    Conclusions

    Low bioavailability is a central obstacle to clinical efficacy of horny goat weed preparations.

    Limitations

    Preclinical pharmacokinetics; limited human data.

    Supplements Studied

    Icariin has poor oral bioavailability and extensive first-pass metabolism.

    Study Details

    Year:2015
    00
    Quality Score:6/10

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