Berberine activates thermogenesis in white and brown adipose tissue
Zhang Z, Zhang H, Li B, Meng X, Wang J, Zhang Y, Yao S, Ma Q, Jin L, Yang J, Wang W, Ning G
Published in Nature Communications
Methodology
Preclinical rodent and cell studies of berberine effects on brown and white adipose thermogenic gene expression
Key Findings
Berberine increased energy expenditure, raised brown adipose activity and induced browning of white adipose tissue via AMPK-PGC1alpha signalling.
Conclusions
Berberine promotes adipose browning in animal models; human confirmation is lacking.
Limitations
Animal and cell data only; no human browning trial exists.
Supplements Studied
Berberine induced browning of white adipose tissue in animal models.
Outcomes Measured
Berberine induced browning of white adipose tissue via AMPK-PGC1alpha signalling.
Study Details
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Disclosures
Funding
Chinese national research grants
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