Trehalose as a chemical chaperone in neurodegenerative disease: preclinical and early clinical evidence
Khalifeh M, Barreto GE, Sahebkar A
Published in British Journal of Pharmacology
Methodology
Review of preclinical and early clinical studies of trehalose on autophagy induction and clearance of misfolded protein aggregates.
Key Findings
Trehalose enhanced autophagy and reduced aggregation of misfolded proteins in animal models, with limited and inconclusive human data.
Conclusions
Chemical chaperone effects have not yet translated to human supplementation outcomes.
Limitations
Poor oral bioavailability; no adequately powered human trials.
Outcomes Measured
Trehalose enhanced autophagy and reduced aggregation of misfolded proteins in animal models, with limited and inconclusive human data
Study Details
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