Systematic review of treatments for diabetic peripheral neuropathy
Çakici N, Fakkel TM, van Neck JW, Verhagen AP
Published in Diabetic Medicine
Methodology
Systematic review and random-effects meta-analysis of 27 randomized controlled trials of treatments for diabetic peripheral neuropathy of the feet.
Key Findings
Alpha-lipoic acid 600 mg intravenously reduced total symptom score by -2.45 (95% CI -4.52 to -0.39) versus placebo, with smaller reductions for other regimens.
Conclusions
Alpha-lipoic acid shows symptom benefit in diabetic peripheral neuropathy, but the evidence base is heterogeneous.
Limitations
Few trials per treatment, short follow-up, variable risk of bias.
Supplements Studied
In the meta-analysis of trials of α-lipoic acid versus placebo, total symptom score was reduced by -2.45 (95% CI -4.52; -0.39) with 600 mg i.v. α-lipoic acid
Related Health Concerns
Study Details
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Disclosures
Funding
Not reported
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