Ascorbic acid supplements and kidney stone incidence among men: a prospective study
Thomas LD, Elinder CG, Tiselius HG, Wolk A, Akesson A
Published in JAMA Intern Med, Vol. 173 (5), pp. 386-8
Methodology
Population-based prospective cohort (Cohort of Swedish Men): 23,355 men aged 45-79 without prior stones and not using other supplements, followed through national registers from 1998 to 2009.
Key Findings
436 first stones. Men using ascorbic acid supplements only (907 men, 31 stones) had about twice the risk of non-users (multivariable RR 1.92, 95% CI 1.33 to 2.77), rising with frequency of use (7 or more tablets a week: RR 2.23). Multivitamin use was not linked to stones (RR 0.86).
Conclusions
High-dose ascorbic acid supplements were associated with a dose-dependent 2-fold higher risk of kidney stones in men.
Limitations
Observational research letter; dose inferred (Swedish tablets typically 1,000 mg); men only; residual confounding possible. PubMed has no abstract; figures from the full text.
Supplements Studied
dose-dependent 2-fold increased risk of kidney stone formation among men
Related Health Concerns
Study Details
Access Study
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.