Alpha-lipoic acid effect on leptin and adiponectin concentrations: a systematic review and meta-analysis of randomized controlled trials
Haghighatdoost F, Gholami A, Hariri M
Published in European Journal of Clinical Pharmacology, Vol. 76 (5), pp. 649-657
Methodology
Meta-analysis of randomized trials of alpha-lipoic acid reporting leptin and adiponectin concentrations.
Key Findings
Alpha-lipoic acid significantly reduced circulating leptin alongside modest weight reduction.
Conclusions
Alpha-lipoic acid lowers leptin concentrations, consistent with improved energy-balance signalling.
Limitations
Short trial durations; most trials in metabolic disease populations.
Supplements Studied
Alpha-lipoic acid significantly reduced circulating leptin alongside modest weight reduction
Outcomes Measured
Alpha-lipoic acid significantly reduced circulating leptin alongside modest weight reduction
Study Details
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