Remedy Routes
    meta_analysis
    2018
    High Quality

    The effects of alpha-lipoic acid supplementation on glucose control and lipid profiles among patients with metabolic diseases: A systematic review and meta-analysis of randomized controlled trials

    Akbari M, Ostadmohammadi V, Tabrizi R, Lankarani KB, Heydari ST, Amirani E

    Published in Metabolism, Vol. 87, pp. 56-69

    Methodology

    Meta-analysis of randomized trials of alpha-lipoic acid reporting fasting glucose, insulin and HOMA-IR.

    Key Findings

    Alpha-lipoic acid significantly reduced fasting insulin and HOMA-IR, indicating improved insulin-mediated substrate handling.

    Conclusions

    Alpha-lipoic acid improves insulin sensitivity, an upstream determinant of metabolic flexibility.

    Limitations

    Populations mostly metabolic disease; heterogeneity in dosing.

    Supplements Studied

    Alpha-lipoic acid significantly reduced fasting insulin and HOMA-IR

    Outcomes Measured

    Metabolic Flexibility

    Alpha-lipoic acid significantly reduced fasting insulin and HOMA-IR

    Insulin Sensitivity

    Alpha-lipoic acid significantly reduced fasting insulin and HOMA-IR, indicating improved insulin-mediated substrate handling.

    Study Details

    Year:2018
    Duration:12 weeks
    Quality Score:7/10

    Access Study

    View on DOIView on PubMedOriginal Source

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