Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: results of a randomized clinical trial in China
Egner PA, Chen JG, Zarth AT, Ng DK, Wang JB, Kensler KH, Jacobson LP, Munoz A, Johnson JL, Groopman JD, Fahey JW, Talalay P, Zhu J, Chen TY, Qian GS, Carmella SG, Hecht SS, Kensler TW
Published in Cancer Prevention Research
Methodology
Randomized clinical trial of a sulforaphane-yielding broccoli sprout beverage in 291 adults in a polluted region of China over 12 weeks.
Key Findings
Urinary excretion of benzene and acrolein conjugates increased rapidly and was sustained, indicating enhanced phase II detoxification.
Conclusions
Sulforaphane accelerates excretion of airborne pollutants via NRF2-mediated detoxification enzymes.
Limitations
Biomarker endpoints only; no clinical disease outcomes.
Supplements Studied
Sulforaphane accelerates excretion of airborne pollutants via NRF2-mediated detoxification enzymes.
Outcomes Measured
Urinary excretion of benzene and acrolein conjugates increased rapidly and was sustained, indicating enhanced phase II detoxification.
Sulforaphane accelerates excretion of airborne pollutants via NRF2-mediated detoxification enzymes.
Study Details
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