meta_analysis
    2016
    High Quality

    N-acetylcysteine for depressive symptoms and reward processing: a systematic review and meta-analysis

    Fernandes BS, Dean OM, Dodd S, Malhi GS, Berk M

    Published in Journal of Clinical Psychiatry

    Methodology

    Meta-analysis of randomized placebo-controlled trials of N-acetylcysteine on depressive symptoms and functional outcomes.

    Key Findings

    NAC significantly improved depressive symptoms and functioning versus placebo with a small to moderate effect.

    Conclusions

    NAC's glutamatergic action supports reward-related symptom improvement.

    Limitations

    Small number of trials; mixed diagnoses.

    Supplements Studied

    NAC significantly improved depressive symptoms and functioning versus placebo

    Outcomes Measured

    Pleasure Response Restoration

    NAC significantly improved depressive symptoms and functioning versus placebo with a small to moderate effect

    Study Details

    Year:2016
    Sample Size:574
    Duration:20 weeks
    Quality Score:7/10

    Access Study

    View on DOIView on PubMedOriginal Source

    This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.