Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline
Schwarz C, Stekovic S, Wirth M, Benson G, Royer P, Sigrist SJ, Pieber T, Dammbrueck C, Magnes C, Eisenberg T, Pendl T, Bohlken J, Kobe T, Madeo F, Floel A
Published in Aging
Methodology
Randomized, placebo-controlled dose-finding safety study of spermidine-rich wheat germ extract in older adults, with parallel mouse toxicity work.
Key Findings
Supplementation was safe and well tolerated with no relevant adverse effects on renal, hepatic or haematologic parameters.
Conclusions
Spermidine supplementation at the tested doses appears safe for older adults over three months.
Limitations
Short duration; safety, not efficacy, endpoints.
Supplements Studied
Spermidine supplementation at the tested doses appears safe for older adults over three months.
Related Health Concerns
Study Details
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