Oral magnesium therapy improves endothelial function in patients with coronary artery disease
Shechter M, Sharir M, Labrador MJ, Forrester J, Silver B, Bairey Merz CN
Published in Circulation
Methodology
Randomised double-blind placebo-controlled crossover trial of oral magnesium oxide 730 mg/day for 6 months in patients with stable coronary artery disease.
Key Findings
Brachial artery flow-mediated dilation improved significantly and exercise-induced chest pain and ischaemia measures were better with magnesium than placebo.
Conclusions
Oral magnesium improves endothelial function and exercise tolerance in stable coronary artery disease.
Limitations
Small single-centre trial; surrogate endpoints; predates modern statin-era therapy.
Supplements Studied
Brachial artery flow-mediated dilation improved and exercise-induced ischaemia measures were better with oral magnesium than placebo.
Outcomes Measured
Brachial artery flow-mediated dilation improved significantly with six months of oral magnesium in coronary artery disease.
Related Health Concerns
Study Details
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