Regression of gastroesophageal reflux disease symptoms using dietary supplementation with melatonin, vitamins and aminoacids: comparison with omeprazole
Pereira RS
Published in Journal of Pineal Research
Methodology
Single-blind randomized study comparing a supplement containing melatonin, L-tryptophan, vitamin B6, folic acid, vitamin B12, methionine and betaine in 176 patients against omeprazole 20 mg in 175 patients with GERD
Key Findings
The melatonin-containing combination produced symptom regression comparable to omeprazole in this single-blind trial.
Conclusions
A frequently cited but methodologically weak trial of a multi-ingredient formula, not melatonin alone.
Limitations
Single-blind; single investigator; multi-ingredient product; results never independently replicated.
Supplements Studied
Melatonin has known inhibitory activities on gastric acid secretion and nitric oxide biosynthesis.
Related Health Concerns
Study Details
Access Study
Disclosures
Funding
Not reported
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.