systematic_review
    2019

    Berberine-containing plants: safety, drug interactions and contraindications

    Imenshahidi M, Hosseinzadeh H

    Published in Phytotherapy Research

    Key Findings

    Berberine-containing botanicals inhibit CYP3A4 and P-glycoprotein and are contraindicated in pregnancy and in neonates because of kernicterus risk.

    Conclusions

    Interaction and pregnancy risks are the key safety issues.

    Limitations

    Narrative safety review.

    Supplements Studied

    Berberine-containing botanicals inhibit CYP3A4 and are contraindicated in pregnancy and in neonates.

    Berberine
    Compound

    Berberine-containing botanicals inhibit CYP3A4 and P-glycoprotein and are contraindicated in pregnancy and in neonates because of kernicterus risk.

    Study Details

    Year:2019
    Quality Score:6/10

    Access Study

    View on DOIView on PubMedOriginal Source

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