systematic_review
    2015
    High Quality

    Manganese is essential for neuronal health

    Horning KJ, Caito SW, Tipps KG

    Published in Annual Review of Nutrition

    Key Findings

    Manganese is required for antioxidant and metabolic enzymes, but both deficiency and excess cause neurological dysfunction in a U-shaped dose response.

    Conclusions

    Narrow optimal intake window.

    Limitations

    Mechanistic and observational evidence.

    Supplements Studied

    Manganese
    Mineral

    Both manganese deficiency and excess cause neurological dysfunction, following a U-shaped dose response.

    Study Details

    Year:2015
    Quality Score:7/10

    Access Study

    View on DOIView on PubMedOriginal Source

    This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.