systematic_review
    2006
    High Quality

    Toxicity of methionine in humans

    Garlick PJ

    Published in Journal of Nutrition

    Key Findings

    Single doses above roughly 100 mg/kg produce marked plasma methionine and homocysteine elevations with nausea and cognitive changes; chronic safe intake is poorly defined.

    Conclusions

    Supplemental methionine has a narrow safety margin.

    Limitations

    Few controlled chronic dosing studies.

    Supplements Studied

    L-Methionine
    Amino Acid

    Single methionine doses above about 100 mg/kg cause marked plasma homocysteine elevation with nausea and cognitive changes.

    Study Details

    Year:2006
    Quality Score:7/10

    Access Study

    View on DOIView on PubMedOriginal Source

    This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.