rct
    2011
    High Quality

    Disease-modifying properties of long-term lithium treatment for amnestic mild cognitive impairment: randomised controlled trial

    Forlenza OV, Diniz BS, Radanovic M

    Published in British Journal of Psychiatry

    Key Findings

    Low-dose lithium over 12 months was associated with better attention performance and lower CSF phosphorylated tau, but no benefit on primary cognitive composites.

    Conclusions

    Mixed result at therapeutic-adjacent doses, not orotate salts.

    Limitations

    Small sample, surrogate biomarkers.

    Supplements Studied

    Low-dose lithium improved attention and reduced CSF phosphorylated tau, but did not improve the primary cognitive outcomes.

    Related Health Concerns

    Cognitive Decline
    Mild Cognitive Impairment

    Study Details

    Year:2011
    Sample Size:45
    Duration:52 weeks
    Quality Score:7/10

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    This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.