Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality
Miller ER, Pastor-Barriuso R, Dalal D, Riemersma RA, Appel LJ, Guallar E
Published in Annals of Internal Medicine
Methodology
Dose-response meta-analysis of 19 randomised trials including 135,967 participants receiving vitamin E alone or with other nutrients.
Key Findings
Doses of 400 IU/day or more were associated with increased all-cause mortality (risk difference 39 per 10,000 persons).
Conclusions
High-dosage vitamin E supplementation may increase all-cause mortality and should be avoided.
Limitations
Most trials enrolled chronically ill older adults; dose-response modelling assumptions contested.
Supplements Studied
High-dosage vitamin E supplementation (400 IU/day or more) may increase all-cause mortality.
Outcomes Measured
High-dose antioxidant vitamin E supplementation was associated with increased all-cause mortality.
Related Health Concerns
Study Details
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This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.