Rhodiola rosea in subjects with prolonged or chronic fatigue symptoms: results of an open-label clinical trial

Lekomtseva Y, Zhukova I, Wacker A

Published in Complementary Medicine Research, Vol. 24, pp. 46-52

Methodology

Uncontrolled, open-label multicentre trial; 100 subjects with prolonged or chronic fatigue took 2 x 200 mg of dry ethanolic extract WS 1375 for 8 weeks with exploratory fatigue scales and tests.

Key Findings

The greatest change was observed after 1 week of treatment, and fatigue symptoms continued to decline with statistically significant improvement at week 8; tolerability was favourable.

Conclusions

WS 1375 at 2 x 200 mg daily may be an effective and well-tolerated treatment for prolonged or chronic fatigue, though the design is hypothesis-generating only.