Effects and safety of periconceptional oral folate supplementation for preventing birth defects
De-Regil LM, Pena-Rosas JP, Fernandez-Gaxiola AC, Rayco-Solon P
Published in Cochrane Database of Systematic Reviews
Methodology
Cochrane review of randomised trials of periconceptional folic acid supplementation for prevention of neural tube defects and other birth outcomes.
Key Findings
Folic acid supplementation before and in early pregnancy produced a large protective effect against neural tube defects.
Conclusions
Periconceptional folic acid is a core pregnancy-support intervention.
Limitations
No effect shown on other birth defects or miscarriage.
Supplements Studied
Folic acid supplementation before and in early pregnancy produced a large protective effect against neural tube defects
Outcomes Measured
Folic acid supplementation before and in early pregnancy produced a large protective effect against neural tube defects
Study Details
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This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.