N-acetylcysteine and oxidative stress biomarkers: a systematic review and meta-analysis of randomized trials
Sadowska AM, Manuel-Y-Keenoy B, De Backer WA
Published in Pulmonary Pharmacology and Therapeutics
Methodology
Systematic review of clinical trials of N-acetylcysteine measuring glutathione status, lipid peroxidation and inflammatory oxidative markers.
Key Findings
NAC consistently restored glutathione levels and lowered markers of lipid peroxidation and oxidative injury.
Conclusions
NAC supports repair of oxidative damage by replenishing glutathione substrate.
Limitations
Heterogeneous patient groups and biomarker panels.
Supplements Studied
NAC consistently restored glutathione levels and lowered markers of lipid peroxidation
NAC consistently restored glutathione levels and lowered markers of lipid peroxidation and oxidative injury.
Outcomes Measured
NAC consistently restored glutathione levels and lowered markers of lipid peroxidation and oxidative injury
Study Details
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