Comparative Effectiveness of Oral Drug Therapies for Lower Urinary Tract Symptoms due to Benign Prostatic Hyperplasia: A Systematic Review and Network Meta-Analysis
Yuan J., Liu Y., Yang Z., Qin X., Yang K., Mao C., Wang X.
Published in PLoS ONE
Abstract
This systematic review and network meta-analysis compared the comparative effectiveness of oral drug therapies for lower urinary tract symptoms due to benign prostatic hyperplasia.
Methodology
Systematic search for RCTs of oral pharmacotherapies for BPH-related LUTS; network meta-analysis comparing drug classes and combinations.
Key Findings
Combination therapy generally provided greater symptom improvement than monotherapy; alpha-blockers provided rapid relief while 5-alpha reductase inhibitors reduced long-term progression.
Conclusions
Combination pharmacotherapy offers superior symptom control for moderate-to-severe BPH-related LUTS compared with monotherapy.
Limitations
Network meta-analysis relies on indirect comparisons; inconsistency in outcome reporting; possible publication bias among industry-sponsored trials.
Related Health Concerns
Study Details
Access Study
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.