meta_analysis
    2019

    Prokinetics and ghrelin for the management of cancer cachexia syndrome

    Malik JS, Yennurajalingam S

    Published in Annals of Palliative Medicine

    Methodology

    Review with meta-analysis of randomized trials of anamorelin (50 and 100 mg/day) and prokinetic agents for cancer cachexia and anorexia.

    Key Findings

    Anamorelin increased total body weight and lean body mass versus baseline, but did not improve overall survival or hand grip strength.

    Conclusions

    Ghrelin-receptor agonists improve weight and appetite markers without demonstrated functional or survival benefit.

    Limitations

    Review design, limited trial pool, and outcomes largely restricted to cancer cachexia populations.

    Related Health Concerns

    Loss of Appetite

    Study Details

    Year:2019
    Quality Score:6/10

    Access Study

    View on DOIView on PubMedOriginal Source

    Disclosures

    Funding

    Not reported

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