Citicoline and membrane phospholipid synthesis in the human brain: a review
Wurtman RJ, Cansev M, Ulus IH
Published in Journal of Nutrition, Health and Aging
Methodology
Review of human and animal studies of CDP-choline on phosphatidylcholine synthesis, dendritic spine density and synaptic membrane formation.
Key Findings
Citicoline increased brain phosphatide levels and dendritic spine density, supporting formation of new synaptic membrane.
Conclusions
Citicoline supplies substrate for synaptic membrane growth.
Limitations
Mechanistic emphasis; limited clinical endpoints.
Supplements Studied
Citicoline increased brain phosphatide levels and dendritic spine density
Outcomes Measured
Citicoline increased brain phosphatide levels and dendritic spine density, supporting formation of new synaptic membrane
Study Details
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