The effects of coenzyme Q10 supplementation on biomarkers of exercise-induced muscle damage, physical performance, and oxidative stress: a GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials
Talebi S, Pourgharib Shahi MH, Zeraattalab-Motlagh S, Asoudeh F, Ranjbar M, Hemmati A
Published in Clinical Nutrition ESPEN
Methodology
GRADE-assessed systematic review and dose-response meta-analysis of 28 randomized controlled trials with 830 adults on coenzyme Q10 and exercise-induced muscle damage, performance and oxidative stress
Key Findings
CoQ10 reduced creatine kinase (WMD -50.64 IU/L), lactate dehydrogenase (WMD -52.10 IU/L), myoglobin (WMD -21.77 ng/ml) and malondialdehyde (WMD -0.73 umol/l), with no significant change in total antioxidant capacity.
Conclusions
CoQ10 attenuates markers of exercise-induced muscle damage and oxidative stress, though effects on performance itself are more modest.
Limitations
Heterogeneous doses and populations; biomarker rather than clinical endpoints dominate.
Supplements Studied
CoQ10 supplementation significantly decreased creatine kinase (CK) (WMD: -50.64 IU/L; 95 %CI: -74.75, -26.53, P < 0.001)
Related Health Concerns
Study Details
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Disclosures
Funding
Not reported
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.