Effects of Resveratrol on Memory and Cognitive Function
Witte AV, Kerti L, Margulies DS, Flöel A
Published in Journal of Neuroscience
Abstract
Randomized controlled trial showing resveratrol supplementation improves memory performance and functional connectivity in older adults.
Methodology
Randomised, double-blind, placebo-controlled trial with resting-state fMRI, memory testing and metabolic biomarkers over 26 weeks.
Key Findings
In 23 healthy overweight older adults, resveratrol 200 mg/day for 26 weeks improved verbal memory retention and increased hippocampal functional connectivity relative to placebo, accompanied by lower HbA1c and higher body-fat-adjusted metabolic markers.
Conclusions
Resveratrol produced a measurable memory and hippocampal connectivity benefit in older adults over six months — an encouraging but small pilot-scale signal that has not been confirmed in larger trials.
Limitations
Very small sample, healthy volunteers, multiple neuroimaging and cognitive comparisons, and no replication at scale; resveratrol bioavailability is poor and dose-response is unclear.
Supplements Studied
In 23 healthy overweight older adults, resveratrol 200 mg/day for 26 weeks improved verbal memory retention and increased hippocampal functional connectivity relative to placebo, accompanied by lower HbA1c and higher body-fat-adjusted metabolic markers.
Outcomes Measured
In 23 healthy overweight older adults, resveratrol 200 mg/day for 26 weeks improved verbal memory retention and increased hippocampal functional connectivity relative to placebo, accompanied by lower HbA1c and higher body-fat-adjusted metabolic markers.
Study Details
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Disclosures
Funding
German Research Foundation and academic grants
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