Biotin Interference in Immunoassays and Patient Safety
Dasgupta A, Yeo KJ
Published in American Journal of Clinical Pathology
Abstract
Review of biotin interference in clinical immunoassays and its patient safety implications.
Key Findings
High-dose biotin supplementation can cause falsely high or falsely low results in biotin-streptavidin immunoassays, including thyroid and troponin tests, with documented patient harm.
Conclusions
High-dose biotin should be withheld before laboratory testing.
Limitations
Review of case reports and analytical studies; interference varies by platform.
Supplements Studied
High-dose biotin supplementation can cause falsely high or falsely low results in biotin-streptavidin immunoassays, including thyroid and troponin tests, with documented patient harm.
Study Details
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This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.