rct
    2012
    High Quality

    The Effect of Magnesium Supplementation on Primary Insomnia in Elderly

    Abbasi B, Kimiagar M, Sadeghniiat K, Shirazi MM

    Published in Journal of Research in Medical Sciences

    Abstract

    Double-blind placebo-controlled trial showing magnesium supplementation improved subjective measures of insomnia, sleep efficiency, sleep time, and sleep onset latency in elderly subjects.

    Methodology

    Double-blind, placebo-controlled trial with 46 elderly subjects (aged 60+ years) with primary insomnia. Participants received 500mg elemental magnesium or placebo daily for 8 weeks. Sleep quality assessed using Pittsburgh Sleep Quality Index (PSQI), Insomnia Severity Index (ISI), and polysomnography. Blood samples analyzed for serum magnesium, melatonin, and cortisol.

    Key Findings

    Magnesium supplementation significantly improved PSQI scores (p<0.05) Significant increase in sleep time by 42 minutes (p<0.001) Improved sleep efficiency from 74% to 85% (p<0.001) Reduced early morning awakening frequency (p<0.01) Increased serum melatonin concentration (p<0.05) Decreased serum cortisol levels (p<0.05) Reduced sleep onset latency by 17 minutes

    Conclusions

    Magnesium supplementation significantly improved sleep quality, sleep time, and sleep efficiency in elderly subjects with primary insomnia. The mechanism may involve regulation of melatonin and cortisol levels. Magnesium supplementation appears to be a safe and effective intervention for age-related insomnia.

    Limitations

    Small sample size (n=46) limits generalizability Limited to elderly population - results may not apply to younger adults Single-center study in Iran Relatively short 8-week duration Did not compare different magnesium forms No long-term follow-up after supplementation stopped

    Supplements Studied

    Magnesium
    Mineral

    Magnesium supplementation significantly improved PSQI scores (p<0.05) Significant increase in sleep time by 42 minutes (p<0.001) Improved sleep efficiency from 74% to 85% (p<0.001) Reduced early morning awakening frequency (p<0.01) Increased serum melatonin concentration (p<0.05) Decreased serum cortisol levels (p<0.05) Reduced sleep onset latency by 17 minutes

    Melatonin
    Compound

    Magnesium supplementation significantly improved PSQI scores (p<0.05) Significant increase in sleep time by 42 minutes (p<0.001) Improved sleep efficiency from 74% to 85% (p<0.001) Reduced early morning awakening frequency (p<0.01) Increased serum melatonin concentration (p<0.05) Decreased serum cortisol levels (p<0.05) Reduced sleep onset latency by 17 minutes

    Outcomes Measured

    Magnesium supplementation significantly improved sleep quality, sleep efficiency, sleep time, and reduced sleep onset latency in elderly individuals with insomnia.

    Related Health Concerns

    Study Details

    Year:2012
    Sample Size:46
    Duration:8 weeks
    Quality Score:7/10

    Disclosures

    Funding

    Isfahan University of Medical Sciences

    Conflicts of Interest

    None declared. No pharmaceutical company involvement.

    This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.