Human phase response curves to three days of daily melatonin: 0.5 mg versus 3.0 mg
Burgess HJ, Revell VL, Molina TA, Eastman CI
Published in Journal of Clinical Endocrinology and Metabolism
Methodology
Within-subject laboratory study generating phase response curves for 0.5 mg and 3.0 mg melatonin taken daily for three days, with dim light melatonin onset used to measure circadian phase shifts.
Key Findings
Both doses produced comparable phase advances and delays depending on timing relative to circadian phase, confirming melatonin acts as a chronobiotic whose timing determines the direction of the shift.
Conclusions
Correctly timed low-dose melatonin can shift circadian phase as effectively as higher doses.
Limitations
Small controlled laboratory sample; healthy participants rather than patients with circadian disorders.
Supplements Studied
Both doses produced comparable circadian phase advances and delays depending on timing relative to circadian phase.
Outcomes Measured
Melatonin produced circadian phase advances and delays depending on timing of administration.
Study Details
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Disclosures
Funding
US National Institutes of Health
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