Role of VDR gene polymorphisms and environmental factors in the development of skin cancers: evidence by updated meta-analysis
Tizaoui K, Chikhaoui A, Yacoub-Youssef H
Published in Archives of Dermatological Research
Methodology
Updated meta-analysis of association studies of VDR gene polymorphisms (FokI, BsmI, TaqI, ApaI) and skin cancers, with subgroup analyses by environmental exposure.
Key Findings
FokI CT genotype was associated with increased melanoma risk and BsmI AG with protection; TaqI and ApaI showed no overall melanoma association.
Conclusions
Vitamin D receptor genetics modestly influence skin cancer risk, but this does not establish benefit from vitamin D supplementation.
Limitations
Genetic association data only; no supplementation outcomes; heterogeneity across populations.
Supplements Studied
Meta-analysis showed that the VDR Fok I polymorphism was associated with melanoma risk (CT vs. CC + TT, P = 0.020), with CT genotype as a significant risk factor.
Related Health Concerns
Study Details
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Disclosures
Funding
Not reported
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