Metabolic flexibility as a determinant of metabolic health: a systematic review of interventions
Goodpaster BH, Sparks LM
Published in Cell Metabolism
Methodology
Review of human studies using indirect calorimetry and clamp protocols to assess substrate switching after exercise, diet and supplement interventions.
Key Findings
Exercise training reliably restored substrate switching capacity, while nutritional supplements produced small and inconsistent changes.
Conclusions
Metabolic flexibility responds strongly to exercise and much less to supplementation.
Limitations
Definitions and measurement protocols vary widely between studies.
Outcomes Measured
Exercise training reliably restored substrate switching capacity, while nutritional supplements produced small and inconsistent changes
Study Details
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