rct
    2006
    High Quality

    DHEA supplementation and circulating steroid hormones in older adults: a randomized controlled trial

    Nair KS, Rizza RA, O'Brien P, Dhatariya K, Short KR, Nehra A

    Published in New England Journal of Medicine

    Methodology

    Two-year randomized placebo-controlled trial of DHEA or testosterone replacement in elderly men and women measuring hormone levels, body composition and quality of life.

    Key Findings

    DHEA raised circulating DHEA-S and downstream steroid precursors but produced no improvement in body composition, physical performance, insulin sensitivity or quality of life.

    Conclusions

    Adrenal steroid precursor supplementation shifts hormone levels without functional benefit.

    Limitations

    Older, healthy population; may not generalise to deficiency states.

    Outcomes Measured

    DHEA raised circulating DHEA-S and downstream steroid precursors but produced no improvement in body composition, physical performance or quality of life

    DHEA raised circulating DHEA-S and downstream steroid precursors but produced no improvement in body composition, physical performance, insulin sensitivity or quality of life.

    Study Details

    Year:2006
    Sample Size:87
    Duration:104 weeks
    Quality Score:8/10

    This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.