Alpha lipoic acid for symptomatic peripheral neuropathy in patients with diabetes: a meta-analysis of randomized controlled trials
Mijnhout GS, Kollen BJ, Alkhalaf A, Kleefstra N, Bilo HJG
Published in International Journal of Endocrinology
Key Findings
Intravenous alpha-lipoic acid 600 mg/day for 3 weeks significantly reduced neuropathic pain; oral evidence at 600 mg/day was weaker but suggestive.
Conclusions
ALA provides clinically meaningful short-term symptom relief in diabetic neuropathy, strongest for IV administration.
Limitations
Few oral trials; heterogeneous outcome scales; short follow-up.
Supplements Studied
Alpha lipoic acid for symptomatic peripheral neuropathy in patients with diabetes: a meta-analysis of randomized controlled trials.
Outcomes Measured
Alpha-lipoic acid significantly reduced neuropathic pain in patients with diabetes.
Related Health Concerns
Study Details
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