Vitamin D and Muscle Function in Older Adults
Bischoff-Ferrari HA, Dawson-Hughes B, Orav EJ, Staehelin HB
Published in The American Journal of Clinical Nutrition
Abstract
Study demonstrating vitamin D's effects on muscle strength, physical performance, and fall prevention in elderly populations.
Methodology
Review of mechanistic, observational and randomised trial evidence on 25-hydroxyvitamin D status, muscle strength, balance and fall risk in older adults, with dose-response consideration for supplementation.
Key Findings
This review of trials and observational data concluded that vitamin D acts on skeletal muscle via the vitamin D receptor, that low 25(OH)D is associated with reduced muscle strength, more body sway and higher fall risk in older adults, and that supplementation of roughly 700-1000 IU/day improves balance and reduces falls by around 19%, with little benefit at lower doses.
Conclusions
Adequate vitamin D intake (about 800-1000 IU/day) improves muscle function and reduces falls in older adults, particularly those with low baseline levels.
Limitations
Narrative synthesis rather than a formal meta-analysis with pooled risk-of-bias assessment, heterogeneous dosing regimens and calcium co-supplementation, varying fall ascertainment methods, and benefit dependent on baseline vitamin D status and dose.
Supplements Studied
This review of trials and observational data concluded that vitamin D acts on skeletal muscle via the vitamin D receptor, that low 25(OH)D is associated with reduced muscle strength, more body sway and higher fall risk in older adults, and that supplementation of roughly 700-1000 IU/day improves balance and reduces falls by around 19%, with little benefit at lower doses.
Outcomes Measured
Vitamin D supplementation improves muscle strength and physical performance, reducing fall risk in older adults. It supports neuromuscular function and muscle protein synthesis.
Study Details
Access Study
Disclosures
Funding
Academic and public research funding (Switzerland/USA)
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.