A randomised controlled trial of the effects of galacto-oligosaccharides on the gut-brain axis of young females
Johnstone N, Cohen Kadosh K
Published in Brain, Behavior, and Immunity
Methodology
Randomised double-blind placebo-controlled trial in 83 healthy young females receiving GOS or placebo with microbiota, cognitive and mood assessment
Key Findings
GOS altered gut microbiota composition but did not produce significant improvements in cognition or mood outcomes versus placebo.
Conclusions
Larger and better-powered testing did not replicate earlier positive gut-brain findings for GOS.
Limitations
Healthy, low-symptom population may limit detectable effect.
Supplements Studied
Galacto-oligosaccharides altered gut microbiota composition but did not significantly improve cognition or mood compared with placebo.
Outcomes Measured
Galacto-oligosaccharides altered gut microbiota but did not significantly improve cognitive or mood outcomes.
Study Details
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