TEAS, DHEA, CoQ10, and GH for poor ovarian response undergoing IVF-ET: a systematic review and network meta-analysis
Zhu F, Yin S, Yang B, Li S, Feng X, Wang T, Che D
Published in Reproductive Biology and Endocrinology
Methodology
Systematic review and Bayesian network meta-analysis of 16 randomized controlled trials of adjuvant DHEA, CoQ10, growth hormone or TEAS before IVF-ET in women with poor ovarian response (Bologna criteria).
Key Findings
CoQ10 (OR 2.22, 95% CI 1.05-4.71) and DHEA (OR 1.92, 95% CI 1.16-3.16) improved clinical pregnancy rate; CoQ10 ranked best for live birth (OR 2.36, 95% CI 1.07-5.38). No adjuvant significantly reduced cycle cancellation.
Conclusions
Adjuvant CoQ10, DHEA and growth hormone before IVF may improve pregnancy outcomes in poor ovarian responders, but direct-comparison trials are needed.
Limitations
Indirect network comparisons, small individual trials, many from a single region, and no reduction in cycle cancellation rate.
Outcomes Measured
CoQ10 (OR 2.22, 95% CI: 1.05 to 4.71) and DHEA (OR 1.92, 95% CI: 1.16 to 3.16) had obvious advantages in improving the clinical pregnancy rate. CoQ10 was the best in improving the live birth rate (OR 2.36, 95% CI: 1.07 to 5.38)
Study Details
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Disclosures
Funding
Not reported
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